Clergyman's

“I read a page of Plato’s great work. I can no longer understand anything, because behind the words on the page, which have their own heavenly brightness, to be sure, there shines an even brighter, an enormous, dazzling -why- that blots out everything, cancels out, destroys all meaning. All individual intelligence. When one has understood, one stops, satisfied with what one has understood. I do not understand. Understanding is far too little. To have understood is to be fixed, immobilized. It is as though one wanted to stop on one step in the middle of a staircase, or with one foot in the void and the other on the endless stair. But a mere why, a new why can set one off again, can unpetrify what was petrified and everything starts flowing afresh. How can one understand? One cannot.”
— Eugène Ionesco

“The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine ‘mutational neighbours.’ Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution.”
— Michael G Cordingley

“Still there are people who grasp freedom at once, who don’t doubt, don’t hesitate—but accept themselves as the measure of themselves and of everything, and who don’t seem to show any dread. In some cases there are people who have the strength to do it and the innate wisdom to understand what the price is. In other cases they are people who have no idea what they’re doing, who choose freedom out of ignorance and lack of understanding—they know nothing about any price, and they go under when the price is demanded. It means ruin to choose to think for oneself if one can’t think.”
— Jens Bjørneboe